As a freshman, Signori starred on the Fordham football club, scoring the first touchdown of the season for the Rams and the first score since the sport was dropped in 1954. In 1965, he led the Rams to a 4-1 record as Fordham was selected as the number one club team in the country by the Associated Press. In 1966, he again led the Rams in scoring while in 1967 he led the team in rushing and scoring and finished his career with 78 points.
 
Following graduation, Signori signed with the Westchester Bulls of the Atlantic Coast Football league, a farm club of the New York Giants.