A four-year starter, John Skelton wrapped up a record-shattering career for the Rams as a senior in 2009, closing out the year completing 284 of 441 passes (64.4%) for 3,708 yards and 26 touchdowns, setting new school marks for completions, passing yards and completion percentage. He earned Second Team All-Patriot League honors that season.
 
Skelton led the NCAA FCS in passing yards/game (337.09) in 2009 and was ranked second in total offense (348.18 yards/game), fourth in completions per game (25.82) and total passing yards and tenth in passing efficiency (149.95). He threw for over 300 yards eight times in eleven games that fall, including four 400-yard games. Skelton completed 20 of 27 passes for 420 yards and five touchdowns against Cornell, breaking the school record for passing yards in a game, and then reset his own record two weeks later, completing 43 of 67 passes for 427 yards, all school records, against Holy Cross (he finished one passing attempt shy of the NCAA FCS record for most pass attempts in a game without an interception).
 
Twice named a Preseason All-American by Consensus Draft Services, Skelton graduated with school career records for most completions (802), passing yards (9,923) and touchdown passes (69) as well as single season records for completions (284), completion percentage (.644) and passing yards (3,708).
 
Following his senior year, Skelton was selected to play in the prestigious East-West Shrine game and he received an invitation to the NFL Combine. He was drafted in the fifth round of the 2010 NFL draft by the Arizona Cardinals becoming the 18th Ram to be drafted by an NFL team, the first since Kenny Parker in 1968.